Vitamin D3 (Cholecalciferol)

The Sunshine Vitamin for Bones & Immunity

A fat-soluble vitamin essential for strengthening bones, immune defence, and muscle function, widely recognised as one of the most important nutrients for maintaining overall health.

What is Vitamin D3 Good For?

Vitamin D3 regulates calcium and phosphorus absorption, supporting bone mineralisation and muscle performance. It also plays a critical role in immune regulation and has been associated with improved mood.

 

Vitamin D3 supplementation may lead to:

  • Maintenance of normal bones and teeth through improved calcium and phosphorus absorption
  • Improved immune defense during viral infections (resulting in reduced risk of hospitalisation and faster recovery)
  • Reduced risk of depression through regulation of neurological pathways
  • Maintenance of normal muscle functions and reduction of muscle weakness in deficient individuals
  • Reduction of blood pressure in older adults (>50  years) when taken daily for long term (> 6 months)
  • Decrease in inflammation

What is Vitamin D3?

Vitamin D exists in two primary forms: D2 (ergocalciferol) and D3 (cholecalciferol). Vitamin D3 is the most bioactive and effective form, identical to the vitamin D synthesised in human skin when exposed to sunlight.

 

Modern lifestyles often limit sun exposure, making supplementation the most reliable way to maintain adequate levels, especially during winter months.

What is the Recommended Daily Dose of Vitamin D3?

The EU NRV (Nutrient Reference Value) for vitamin D is 20 µg (800 IU) per day, sufficient to maintain bone and immune system in adults. Higher doses (1000–2000 IU) are often recommended in clinical practice, especially in populations with limited sun exposure.

Things to Know

Source

Typically derived from lanolin (sheep’s wool) or vegan lichen-based sources

Technology

Oil-based softgels, microencapsulation, or spray-dried powders improve absorption

Region

Globally recognised essential vitamin with established NRVs

Data

Supported by extensive EFSA and WHO evaluations on bone, muscle, and immune system

Vitamin D3 in Detail

Clinical Dose
Clinical Dose

20 µg (800 IU, EU NRV)

Source
Source

Cholecalciferol (vegan lichen origin)

Technology
Technology

Oil-based or encapsulated forms for optimal bioavailability

Key Benefits
Key Benefits
  • Maintains bone and tooth strength by regulating calcium absorption
  • Improves immune defence and lowers inflammation
  • Enhances muscle strength 
  • Contributes to improved mood
  • Most bioactive form of vitamin D, superior to D2
Data
Data

Validated by decades of human research and regulatory consensus worldwide

Your Questions About Vitamin D3

Reach us arrow_forward
It’s the bioactive form of vitamin D, produced naturally in the skin with sunlight exposure and essential for bone, muscle, and immune health.
It strengthens bones, supports the immune system, regulates calcium absorption, and improves muscle function.
Vitamin D3 is more potent, longer-lasting, and more effective at raising and maintaining blood 25(OH)D levels than vitamin D2.
Vitamin D is safe at recommended doses. Excessive intake (>100 µg or 4000 IU/day) can cause hypercalcaemia and should be avoided without medical supervision.
Yes, it works synergistically with calcium, magnesium, and vitamin K2 for bone and cardiovascular health.

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References

The Science That Supports Us

Cognitive and Neurological Support

Bislev, L.S. et al. (2022) ‘Effect of daily vitamin D3 supplementation on Muscle Health: An individual participant meta-analysis’, The Journal of Clinical Endocrinology & Metabolism, 107(5), pp. 1317–1327. doi:10.1210/clinem/dgac004. 

Mental Health

EFSA (2010)‘Scientific opinion on the substantiation of health claims related to vitamin D and normal function of the immune system and inflammatory response (ID 154, 159), maintenance of normal muscle function (ID 155) and maintenance of normal cardiovascular function (ID 159) pursuant to Article 13(1) of regulation (EC) no 1924/2006’ (2010) EFSA Journal, 8(2). doi:10.2903/j.efsa.2010.1468. 

Nerve Repair

Golzarand, M. et al. (2016) ‘Effect of vitamin D3 supplementation on blood pressure in adults: An updated meta-analysis’, Nutrition, Metabolism and Cardiovascular Diseases, 26(8), pp. 663–673. doi:10.1016/j.numecd.2016.04.011. 

Immune System Support

Mikola, T. et al. (2022) ‘The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta‐analysis of Randomized Controlled Trials’, Critical Reviews in Food Science and Nutrition, 63(33), pp. 11784–11801. doi:10.1080/10408398.2022.2096560. 

Immune System Support

Sobczak, M. and Pawliczak, R. (2024) ‘Effect of vitamin D3 supplementation on severe covid-19: A meta-analysis of randomized clinical trials’, Nutrients, 16(10), p. 1402. doi:10.3390/nu16101402.

Immune System Support

van Driel, M. and van Leeuwen, J.P.T.M. (2017) ‘Vitamin D endocrinology of bone mineralization’, Molecular and Cellular Endocrinology, 453, pp. 46–51. doi:10.1016/j.mce.2017.06.008.