Vitamin B6 (Pyridoxal-5-Phosphate)

The Active Form of Vitamin B6

The biologically active coenzyme form of vitamin B6, essential for amino acid metabolism, neurotransmitter synthesis, and energy production.

What is Vitamin B6 (P5P) Good For?

Vitamin B6 is vital for over 150 biochemical reactions in the body, particularly those involved in protein metabolism, neurotransmitter production, and red blood cell formation.

 

Supplementing with P5P, the active coenzyme form, bypasses conversion steps required by pyridoxine, making it especially useful for individuals with impaired vitamin B6 metabolism.

 

Vitamin B6 (P5P) supplementation may lead to:

  • Enhanced energy production and reduction of fatigue

  • Enhanced neurotransmitter synthesis (serotonin, dopamine, gamma amino-butyric acid (GABA)) that can enhance mood

  • Hormonal regulation by acting as a cofactor

  • Lowered cardiovascular risks by decreasing homocysteine levels

  • Improved red blood cell formation and oxygen transport

  • Improved immune system through production of T lymphocytes and interleukins

What is Vitamin B6?

Vitamin B6 refers to a group of related compounds (pyridoxine, pyridoxal, pyridoxamine) that must be converted into P5P (pyridoxal-5-phosphate) to become biologically active.

 

Using P5P directly ensures immediate activity in enzymatic pathways, supporting neurological functions, mood, and cardiovascular health.

What is the Recommended Daily Dose of Vitamin B6 (P5P)?

The EU NRV for vitamin B6 is 1.4 mg per day, sufficient to cover normal adult requirements for energy metabolism, neurotransmission, and blood health.

Things to Know

Source

P5P (coenzyme form of vitamin B6), available through advanced synthesis

Technology

Bioactive form eliminates reliance on enzymatic conversion of pyridoxine

Region

Globally recognised essential vitamin with harmonised NRVs

Data

Supported by EFSA and clinical research on B6 status for nervous system, red blood cell formation and immune system

Vitamin B6 (P5P) in Detail

Clinical Dose
Clinical Dose

1.4 mg (EU NRV)

Source
Source

Pyridoxal-5-phosphate (active form of vitamin B6)

Technology
Technology

Delivered as coenzyme-active P5P for immediate metabolic use

Key Benefits
Key Benefits
  • Provides vitamin B6 in its active coenzyme form
  • Reduces fatigue and supports normal energy metabolism
  • Lowers homocysteine levels alongside folate and B12
  • Improves mood through neurotransmitter synthesis
  • Supports immunity, hormonal balance, and blood health
Data
Data

Decades of research confirm vitamin B6’s essential role; P5P is the most efficient and active form

Your Questions About Vitamin B6 (P5P)

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It’s the biologically active coenzyme form of vitamin B6, essential for energy metabolism, neurotransmission, and blood health.
It supports mood, hormones, cardiovascular health, and energy production.
P5P is already in its active form, meaning it doesn’t require conversion in the body and may be more effective for certain individuals.
At nutritional doses, vitamin B6 is safe and well tolerated. Very high chronic intakes (>200 mg/day) may cause peripheral neuropathy.
Yes, it works synergistically with folate (Quatrefolic®) and B12 in methylation, and with riboflavin for energy metabolism.

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References

The Science That Supports Us

Cognitive and Neurological Support

Field, D.T. et al. (2022) ‘High‐dose vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression’, Human Psychopharmacology: Clinical and Experimental, 37(6). doi:10.1002/hup.2852. 

Mental Health

Girgis, V. et al. (2025) ‘Moderate pyridoxal phosphate deficiency enhances neuronal excitability and promotes calcium dysregulation’, Frontiers in Neuroscience, 19. doi:10.3389/fnins.2025.1621349. 

Nerve Repair

Naviaux, R.K. et al. (2016) ‘Metabolic features of chronic fatigue syndrome’, Proceedings of the National Academy of Sciences, 113(37). doi:10.1073/pnas.1607571113. 

Immune System Support

Parra, M., Stahl, S. and Hellmann, H. (2018) ‘Vitamin B6 and its role in cell metabolism and physiology’, Cells, 7(7), p. 84. doi:10.3390/cells7070084.

Immune System Support

Stach, K., Stach, W. and Augoff, K. (2021) ‘Vitamin B6 in health and disease’, Nutrients, 13(9), p. 3229. doi:10.3390/nu13093229. 

Immune System Support

EFSA Panel on Dietetic Products (2009)‘Scientific opinion on the substantiation of health claims related to vitamin B6 and protein and glycogen metabolism (ID 65, 70, 71), function of the nervous system (ID 66), Red Blood Cell Formation (ID 67, 72, 186), function of the immune system (ID 68)’, (2009) EFSA Journal, 7(10), p. 1225. doi:10.2903/j.efsa.2009.1225.