Ingredient
Vitamin B6
The Active Form of Vitamin B6
The biologically active coenzyme form of vitamin B6, essential for amino acid metabolism, neurotransmitter synthesis, and energy production. Involved in over 150 biochemical reactions.
What is Vitamin B6 Good For?
Vitamin B6 is vital for over 150 biochemical reactions in the body, particularly those involved in protein metabolism, neurotransmitter production, and red blood cell formation. Supplementing with P5P bypasses conversion steps required by pyridoxine, making it especially useful for individuals with impaired vitamin B6 metabolism.
Potential benefits of supplementation
- Enhanced energy production and reduction of fatigue
- Enhanced neurotransmitter synthesis (serotonin, dopamine, GABA) that can enhance mood
- Hormonal regulation by acting as a cofactor
- Lowered cardiovascular risks by decreasing homocysteine levels
- Improved red blood cell formation and oxygen transport
- Improved immune system through production of T lymphocytes and interleukins
What is Vitamin B6 (Pyridoxal-5-Phosphate)?
Vitamin B6 refers to a group of related compounds (pyridoxine, pyridoxal, pyridoxamine) that must be converted into P5P (pyridoxal-5-phosphate) to become biologically active.
Using P5P directly ensures immediate activity in enzymatic pathways, supporting neurological functions, mood, and cardiovascular health.
Recommended Daily Dose
1.4 mg (EU NRV)
The EU NRV for vitamin B6 is 1.4 mg per day, sufficient to cover normal adult requirements for energy metabolism, neurotransmission, and blood health.
Vitamin B6 in Detail
- Clinical Dose
- 1.4 mg (EU NRV)
- Source
- Pyridoxal-5-phosphate (P5P, active form of vitamin B6)
- Technology
- Delivered as coenzyme-active P5P for immediate metabolic use
- Key Benefits
- Reduces fatigue and supports normal energy metabolism
- Lowers homocysteine levels alongside folate and B12
- Improves mood through neurotransmitter synthesis (serotonin, dopamine, GABA)
- Supports immunity, hormonal balance, and blood health
- Improves red blood cell formation and oxygen transport
- Data
- Supported by EFSA and clinical research on B6 status for nervous system, red blood cell formation and immune system. Decades of research confirm vitamin B6's essential role; P5P is the most efficient and active form.
Supports
Your Questions About Vitamin B6
What is Vitamin B6 (P5P)?
It's the biologically active coenzyme form of vitamin B6, essential for energy metabolism, neurotransmission, and blood health.
What are the benefits of Vitamin B6 (P5P)?
It supports mood, hormones, cardiovascular health, and energy production.
How is P5P different from pyridoxine?
P5P is already in its active form, meaning it doesn't require conversion in the body and may be more effective for certain individuals.
Are there any side effects?
At nutritional doses, vitamin B6 is safe and well tolerated. Very high chronic intakes (>200 mg/day) may cause peripheral neuropathy.
Can Vitamin B6 (P5P) be combined with other B vitamins?
Yes, it works synergistically with folate (Quatrefolic®) and B12 in methylation, and with riboflavin for energy metabolism.
The Science That Supports Us
- 1Field, D.T. et al. (2022). High-dose vitamin B6 supplementation reducing anxiety and strengthening visual surround suppression. Human Psychopharmacology: Clinical and Experimental, 37(6).
- 2Girgis, V. et al. (2025). Moderate pyridoxal phosphate deficiency and neuronal excitability. Frontiers in Neuroscience, 19.
- 3Naviaux, R.K. et al. (2016). Metabolic features of chronic fatigue syndrome. Proceedings of the National Academy of Sciences, 113(37).
- 4Parra, M., Stahl, S. and Hellmann, H. (2018). Vitamin B6 in cell metabolism and physiology. Cells, 7(7).
- 5Stach, K., Stach, W. and Augoff, K. (2021). Vitamin B6 in health and disease. Nutrients, 13(9).
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