Ingredient
Vitamin B12
The Active Nerve & Energy Vitamin
The biologically active coenzyme form of vitamin B12, essential for red blood cell formation, nervous system, and energy metabolism.
What is Vitamin B12 Good For?
Vitamin B12 supports DNA synthesis, methylation, and neurological functions. Methylcobalamin is the active coenzyme form, directly available for methylation and neurological processes, superior to cyanocobalamin which requires bodily conversion.
Potential benefits of supplementation
- Improved neurological and psychological functions
- Reduced cardiovascular risks through lower homocysteine levels
- Reduced neuropathic symptoms and pain in diabetic patients
- Decreased tiredness and fatigue through red blood cell formation and mitochondrial energy production
- Improved mood and reduced depression via neurotransmitter synthesis
What is Vitamin B12 (Methylcobalamin)?
Vitamin B12 refers to a family of cobalamins, with cyanocobalamin, methylcobalamin, hydroxocobalamin, and adenosylcobalamin as the main forms.
Methylcobalamin is the active coenzyme form, directly available for methylation and neurological processes, superior to cyanocobalamin which requires bodily conversion.
Recommended Daily Dose
2.5 µg (EU NRV)
The EU NRV for vitamin B12 is 2.5 µg per day, sufficient to meet normal adult requirements for energy production, nervous system, and red blood cell formation.
Vitamin B12 in Detail
- Clinical Dose
- 2.5 µg (EU NRV)
- Source
- Methylcobalamin (active coenzyme form of B12, typically via fermentation)
- Technology
- Bioactive form bypasses conversion steps required by cyanocobalamin
- Key Benefits
- Supports DNA synthesis and red blood cell formation
- Reduces fatigue and supports energy metabolism
- Contributes to normal neurological and psychological function
- Lowers homocysteine levels (combined with folate and B6)
- Improves mood and reduces depression
- Data
- Supported by EFSA, WHO, and peer-reviewed clinical studies on neurological and energy production benefits.
Supports
Your Questions About Vitamin B12
What is Vitamin B12 (Methylcobalamin)?
It's the active form of vitamin B12, required for DNA synthesis, red blood cell production, and neurological function.
What are the benefits?
It boosts energy, supports mood and cognition, prevents anaemia, and contributes to cardiovascular health.
How is Methylcobalamin different from cyanocobalamin?
Methylcobalamin is already active in the body, while cyanocobalamin must be converted before it can be used.
Are there side effects?
B12 is safe and well tolerated. Excess intake is excreted in urine, making toxicity very rare.
Can it be combined with other nutrients?
Yes, it works synergistically with folate (Quatrefolic®) and vitamin B6 (P5P) in methylation and homocysteine regulation.
The Science That Supports Us
- 1Sangle, P. et al. (2020). Vitamin B12 supplementation and depression prevention. Cureus.
- 2EFSA (2010). Scientific opinion on B12 contribution to neurological and psychological functions. EFSA Journal, 8(10).
- 3Karedath, J. et al. (2022). Meta-analysis on B12 supplementation in diabetic neuropathy. Cureus.
- 4Sohouli, M.H. et al. (2023). Comprehensive review on B12 supplementation and homocysteine levels. Nutrition Reviews, 82(6).
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